About Us

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SINTESI RESERCH is a Contract Research Organization headquartered in Milan, with regional offices in Tel-Aviv (Israel), Buenos Aires (Argentina), Santiago (Chile), and international strategic partnerships, offering full support in planning, managing and evaluating Phase I-IV Clinical Trials.

We can offer both early and late phase research. Our professional management with global sites and with different culture during clinical trials, makes us unique.

We specialize in EU regulationsFDA regulations and with our partners we can cover other continents regulations.

SINTESI RESERCH has more than 13 years of experience, on time answers and problem solving, together with competitive budget  keeping high level of service.

Paolo De Simoni

Chief Executive Officer


Dr. De Simoni is the founder of Sintesi Research Srl since 2005 and he is responsible for the overall management of the Company and Company’s operations including research and development. He has more than 29 years of experience in the pharmaceutical industry and International CROs. Previously, he held senior business and commercial positions in Medi Services. He was Head of Clinical Operations and Bus. Development in Premier Research Italy, he has served as senior management for Hyperphar Research (now Pierrel Group).. He worked as Senior CRA Astra Farmaceutici before the merger with Zeneca, also as CRA Roussel Maestretti (now SanofiAventis Group). Dr. De Simoni holds a MD PhD degree in Veterinary Medicine from the University of Milano.

Andrea De Martini

Information Technology Manager


Andrea Demartini is responsible of IT management and solutions for Sintesi Research S.r.l. since 2016 and he is responsible of infrastructure and information services. He has more than 20 years of experience in IT, covering system management and maintenance, b2b assistance, retail assistance, network management and system building. Previously he was employed as manager of a retail assistance for five years; he was IT manager of an education company for five years and last run an own business for seven years.

Rachel Jacob

Marketing Director &
Chief Operating Officer

Economy and Marketing degree at Umea University in Sweden. Business development management since 1998 Master in MKTG and CFO since 2005 Founder of several companies in USA and Israel. CFO at Sintesi Research Israel since 2013. Since 2018 she helds the role of COO at Sintesi Research Israel, in which I design and implement business operations, Establish policies that promote company culture and vision. Overseeing operations of the company and the work of executives. Fundraising ventures and participate in expansion activities (investments, acquisitions, corporate alliances etc.) Manage relationships with partners/vendors, and Oversee daily operations of the company and the work of executives (IT, Marketing, Sales, Finance etc.).

Paola Ambroso

Head of Data Management


She was born in São Paulo, Brazil. She received her Bachelor degree in Biology at the University of Milan on 10 December 1990. She works as data manager since 1992. Experience in design of sample CRFs; generation of the database structure and entry screens (Oracle Clinical, PheedIt and ACTide); programming of cleaning checks (Oracle Clinical, PheedIt, ACTide and SAS); medical coding with MedDRA and WHODD; programming with SAS. Experience in these therapeutic areas: Cardiovascular, Hematology, Ophtalmology, Endocrinology and Metabolism, Dermatology, Urology, Gynecology, Medical device.